????????? ? ??????? ??????? ?????????? ???????? ? ?? ?????????? ?? ???????? ??????? ?????????? ???????????? ?????????? ??????? ??????.The crystal structure of DYRK2 in complex with curcumin for the first time showed that curcumin occupies the ATP binding pocket potentially acting as a competitive inhibitor (9). To find out if 4 could inhibit Hck an